ISDA: 9N1P

Deposition Date 2025-01-26

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9N1P

Keywords:

MEMBRANE PROTEIN/AGONIST

Title:

cryo-EM structure of GLP-1R-Gs complex with SRB103H

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Trichoplusia ni, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAS
Mutagens:S54N, G226A, E268A, N271K, K274D, R280K, T284D, I285T, A366S
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63092 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:58
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody 35
Chain IDs:D (auth: N)
Chain Length:128
Number of Molecules:1
Biological Source:Lama glama

UniProt ID:9N1P

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:SRB103H
Chain IDs:E (auth: P)
Chain Length:37
Number of Molecules:1
Biological Source:synthetic construct

UniProt ID:9N1P

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Chain IDs:F (auth: R)
Chain Length:491
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43220 Pfam ID:PF02793, PF00002

Primary Citation

cryo-EM structure of GLP-1R-Gs complex with SRB103H

Zhang, X, Belousoff, M.J, Mohebali, N, Wootten, D, Sexton, P.M.Show

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Primary Citation of related structures

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