ISDA: 9MXU

Deposition Date 2025-01-20

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9MXU

Keywords:

MEMBRANE PROTEIN

Title:

cryo-EM structure of GLP-1R-Gs complex with glucagon

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Lama glama (Taxon ID: 9844)

Expression System(s):

Trichoplusia ni, Synthetic construct, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAS
Chain IDs:C (auth: A)
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63092 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:D (auth: B)
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:E (auth: G)
Chain Length:58
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nb35
Chain IDs:F (auth: N)
Chain Length:128
Number of Molecules:1
Biological Source:Lama glama

UniProt ID:9MXU

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon
Gene (Uniprot):GCG
Chain IDs:B (auth: P)
Chain Length:29
Number of Molecules:1
Biological Source:synthetic construct

UniProt ID:P01273 Pfam ID:PF00123

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Chain IDs:A (auth: R)
Chain Length:491
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43220 Pfam ID:PF02793, PF00002

Ligand Molecules

Primary Citation

cryo-EM structure of GLP-1R-Gs complex with glucagon

Zhang, X, Belousoff, M.J, Wootten, D, Sexton, P.M.Show

To be published ? ? ? (?)

Primary Citation of related structures

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