ISDA: 9MW1

Deposition Date 2025-01-16

Release Date 2026-02-04

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9MW1

Keywords:

LYASE

Title:

Structure of SARM1 TIR domain bound to G8758

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.29

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

P 2 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:NAD(+) hydrolase SARM1
Gene (Uniprot):SARM1
Chain IDs:A (auth: B), B (auth: A)
Chain Length:143
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q6SZW1 Pfam ID:PF13676 EC:3.2.2.6,3.2.2.-

Ligand Molecules

A1BTS

Primary Citation

Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation.

Green, S.A, Smith, R.T, Grandner, J.M, Zeng, M, Del Bel, M, Zhu, B.Y, Liang, J, Braun, M.G, Sudhamsu, J, Wallweber, H.A, Boenig, G, Murray, J, Shen, X, Zhang, R, Lai, K.W, Delwig, A, Breboneria, M.A, Ly, J, Ganti, A, Nespi, M, Weber, M, Leahey, R, Hinz, F.I, Chan, B.K.Show

Acs Med.Chem.Lett. 16 1147 1154 (2025)

PMID: 40529094 DOI: 10.1021/acsmedchemlett.5c00189

Primary Citation of related structures

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