ISDA: 9MSC

Deposition Date 2025-01-09

Release Date 2026-01-14

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9MSC

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Structure of Hepatitis C Virus Envelope Glycoprotein HCV-1 E2ecto from genotype 1a bound to neutralizing antibody RM5-16

Biological Source:

Source Organism(s):

Macaca mulatta (Taxon ID: 9544)
Homo sapiens (Taxon ID: 9606)
Hepatitis C virus (isolate 1) (Taxon ID: 11104)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.39 Å

R-Value Free:

0.31

R-Value Work:

0.27

R-Value Observed:

0.28

Space Group:

P 32 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:HEPC46 fab HC
Chain IDs:D (auth: A)
Chain Length:223
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:HEPC46 fab LC
Chain IDs:C (auth: B)
Chain Length:217
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Envelope glycoprotein E2
Chain IDs:E
Chain Length:262
Number of Molecules:1
Biological Source:Hepatitis C virus (isolate 1)

UniProt ID:P26664

Polymer Type:polypeptide(L)
Molecule:RM5-16 fan HC
Chain IDs:B (auth: H)
Chain Length:224
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:RM5-16 fab LC
Chain IDs:A (auth: L)
Chain Length:216
Number of Molecules:1
Biological Source:Macaca mulatta

Ligand Molecules