9MPW image
Deposition Date 2024-12-31
Release Date 2025-07-09
Last Version Date 2026-03-04
Entry Detail
PDB ID:
9MPW
Keywords:
IMMUNE SYSTEM
Title:
SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment
Biological Source:
Source Organism(s):
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.37 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9MPW validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Fab M15 Heavy Chain
Chain IDs:B (auth: H)
Chain Length:217
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:fAb M15 Light Chain
Chain IDs:C (auth: L)
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Spike protein S2
Gene (Uniprot):S
Chain IDs:A (auth: S)
Chain Length:624
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2
UniProt ID:P0DTC2 Pfam ID:PF01601
Ligand Molecules
NAG
Primary Citation
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope.
Cell Rep 44 116122 116122 (2025)
PMID: 40803328 DOI: 10.1016/j.celrep.2025.116122
Primary Citation of related structures
9MPW
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