9MNS image
Deposition Date 2024-12-23
Release Date 2026-01-14
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9MNS
Keywords:
VIRAL PROTEIN/IMMUNE SYSTEM
Title:
Structure of Hepatitis C virus envelope glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM1-36
Biological Source:
Source Organism(s):
Macaca mulatta (Taxon ID: 9544)
Recombinant Hepatitis C virus HK6a/JFH-1 (Taxon ID: 595609)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.89 Å
R-Value Free:
0.24
R-Value Work:
0.23
R-Value Observed:
0.23
Space Group:
P 1 21 1
9MNS validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Envelope glycoprotein E2
Chain IDs:E, F (auth: B)
Chain Length:231
Number of Molecules:2
Biological Source:Recombinant Hepatitis C virus HK6a/JFH-1
UniProt ID:B9V0E2
Polymer Type:polypeptide(L)
Molecule:RM1-36 Fab heavy chain
Chain IDs:A (auth: H), D (auth: h)
Chain Length:222
Number of Molecules:2
Biological Source:Macaca mulatta
Polymer Type:polypeptide(L)
Molecule:RM1-36 Fab light chain
Chain IDs:B (auth: L), C (auth: l)
Chain Length:211
Number of Molecules:2
Biological Source:Macaca mulatta
Ligand Molecules
NAG
Primary Citation
Structural and genetic signatures of two classes of HCV E2 neutralizing face antibodies from non-human primates immunized with a recombinant E1E2.
Npj Vaccines ? ? ? (2026)
PMID: 42009696 DOI: 10.1038/s41541-026-01449-1
Primary Citation of related structures
9MNS
Feedback Form
Name
Email
Institute
Feedback