ISDA: 9MNM

Deposition Date 2024-12-22

Release Date 2026-01-14

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9MNM

Keywords:

VIRUS LIKE PARTICLE

Title:

SPA of purified HIV-1 CA protein in vitro assembled with IP6 (mature morphology). 500 uM LEN was added post assembly.

Biological Source:

Source Organism(s):

Human immunodeficiency virus type 1 BH10 (Taxon ID: 11678)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:HIV-1 CA
Gene (Uniprot):gag
Chain IDs:A, B, C, D
Chain Length:231
Number of Molecules:4
Biological Source:Human immunodeficiency virus type 1 BH10

UniProt ID:P12493

Ligand Molecules

IHP

QNG

Primary Citation

Lenacapavir prevents production of infectious HIV-1 by abrogating immature virus assembly.

Ricana, C.L, Brancato, S.G, Highland, C.M, Ekbataniamiri, F, Ambrus, K, Rey, J.S, Faerch, M, Torbett, B.E, Perilla, J.R, Dick, R.A.Show

Biorxiv ? ? ? (2026)

PMID: 41867786 DOI: 10.64898/2026.03.02.709178

Primary Citation of related structures

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