ISDA: 9MKG

Deposition Date 2024-12-17

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9MKG

Keywords:

SIGNALING PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of human CD33 bound to 15G15.3 Fab

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Cricetulus griseus, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.45 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:15G15.3 Fab heavy chain
Chain IDs:A
Chain Length:222
Number of Molecules:1
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:15G15.3 Fab light chain
Chain IDs:B
Chain Length:219
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Myeloid cell surface antigen
Gene (Uniprot):CD33
Chain IDs:C
Chain Length:277
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P20138 Pfam ID:PF07686, PF00047

Ligand Molecules

Primary Citation

Rational design of oxidation-resistant antibodies through local electrostatic modulation

Lenka, S, Stephens, N, Mehta, S, Seeger, F, Jafari, N, Liang, W.C, Watkins, A, Kelly, R, Wu, S, Puno, M.R, Azumaya, C, Irudayanathan, J, Zarzar, J, Alavattam, S, Kelley, B, Izadi, S.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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