ISDA: 9MCK

Deposition Date 2025-03-17

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9MCK

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with Leritrelvir

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.82 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Mutagens:M3312I
Chain IDs:A, B
Chain Length:298
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48

Ligand Molecules

7ON

Primary Citation

Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with Leritrelvir

Zhou, X.L, Li, J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form