9LY3 image
Deposition Date 2025-02-19
Release Date 2026-03-04
Last Version Date 2026-09-02
Entry Detail
PDB ID:
9LY3
Keywords:
MEMBRANE PROTEIN
Title:
A Cryo-EM structure of LA-PTH-PTH1R-V2RT-Beta-arrestin1 complex (state 2 conformation)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9LY3 validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:LA-PTH
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta-arrestin-1
Gene (Uniprot):ARRB1
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P49407 Pfam ID:PF00339, PF02752
Polymer Type:polypeptide(L)
Molecule:Fab30H
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:Fab30L
Chain IDs:D (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Parathyroid hormone/parathyro
Gene (Uniprot):AVPR2, PTH1R
Chain IDs:E (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q03431,P30518 Pfam ID:PF02793, PF00002
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP E SER modified residue
TPO E THR modified residue
Ligand Molecules
NA
Primary Citation
Structural basis of PTH1R-beta-arrestin core engagement reveals design principles for G-protein-biased therapeutics.
Nat.Struct.Mol.Biol. 33 868 881 (2026)
PMID: 42115346 DOI: 10.1038/s41594-026-01806-7
Primary Citation of related structures
9LY3
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