ISDA: 9LWE

Deposition Date 2025-02-14

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9LWE

Keywords:

OXIDOREDUCTASE

Title:

P450 hydroxylase THNC

Biological Source:

Source Organism(s):

Streptomyces sp. FXJ1.172 (Taxon ID: 710705)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.90 Å

R-Value Free:

0.23

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:P450
Chain IDs:A
Chain Length:396
Number of Molecules:1
Biological Source:Streptomyces sp. FXJ1.172

UniProt ID:A0A142I751

Ligand Molecules

A1EMA

HEM

Primary Citation

Distinct Oxidoreductases Orchestrate Indolethiophene Skeleton Formation and N-Hydroxylation-Mediated Bioactivation in Thienoxidolin Biosynthesis.

Shi, Y, Zhao, X, Pang, Z, Zhang, X, Xie, Y, Chang, S, Li, X, Li, Y, Li, X, Zhang, X, Jiang, J, Hong, B.Show

Angew.Chem.Int.Ed.Engl. ? e7072895 e7072895 (2026)

PMID: 42275295 DOI: 10.1002/anie.7072895

Primary Citation of related structures

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