9LRN image
Deposition Date 2025-01-31
Release Date 2026-05-27
Last Version Date 2026-05-27
Entry Detail
PDB ID:
9LRN
Keywords:
HYDROLASE
Title:
The crystal structure of PDE2A with 13t
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.50 Å
R-Value Free:
0.30
R-Value Work:
0.24
R-Value Observed:
0.24
Space Group:
P 1
9LRN validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:cGMP-dependent 3',5'-cyclic p
Gene (Uniprot):PDE2A
Chain IDs:A, B, C, D
Chain Length:941
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:O00408 Pfam ID:PF01590, PF00233 EC:3.1.4.17
Ligand Molecules
A1EK7
MG
ZN
Primary Citation
Discovery of A phosphodiesterase 2 Inhibitor Containing 6-fluoroquinoline-8-carboxamide Moiety for the Treatment of Alzheimer's disease
To Be Published ? ? ? (?)
Primary Citation of related structures
9LRN
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