ISDA: 9LQP

Deposition Date 2025-01-28

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9LQP

Keywords:

DNA BINDING PROTEIN/DNA

Title:

Structure of transposase-activated RAG (RAG1 E962N) target capture complex with disordered U-shaped target DNA (TCC-UD)

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.40 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:V(D)J recombination-activatin
Gene (Uniprot):Rag1
Mutagens:E962N
Chain IDs:A, C
Chain Length:750
Number of Molecules:2
Biological Source:Mus musculus

UniProt ID:P15919 Pfam ID:PF00097, PF10426, PF12940, PF26024, PF26025, PF26100, PF26101, PF26104, PF26105 EC:3.1.-.-,2.3.2.27

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Early growth response protein
Gene (Uniprot):Egr1, Rag2
Chain IDs:B, D
Chain Length:457
Number of Molecules:2
Biological Source:Mus musculus

UniProt ID:P08046,P21784 Pfam ID:PF00096, PF03089

Polymer Type:polydeoxyribonucleotide
Molecule:Target DNA bottom strand
Chain IDs:E (auth: I)
Chain Length:59
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:Target DNA top strand
Chain IDs:F (auth: J)
Chain Length:59
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:12RSS top strand
Chain IDs:J (auth: L)
Chain Length:34
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:23RSS top strand
Chain IDs:H (auth: M)
Chain Length:45
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:23RSS bottom strand
Chain IDs:G (auth: x)
Chain Length:45
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:12RSS bottom strand
Chain IDs:I (auth: y)
Chain Length:34
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Structural basis and dynamics of target capture and integration during cut-and-paste transposition

Pang, J, Martin, E.C, Zheng, X, Lu, Q, Schatz, D.G, Zhang, Y.Show

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Primary Citation of related structures

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