9LPK image
Deposition Date 2025-01-25
Release Date 2026-01-28
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9LPK
Keywords:
LIGASE/HYDROLASE
Title:
Structure of human PADI6-UHRF1-UBE2D3 complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.03 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9LPK validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase U
Gene (Uniprot):UHRF1
Chain IDs:A, F
Chain Length:793
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q96T88 Pfam ID:PF00240, PF12148, PF00628, PF02182
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein-arginine deiminase ty
Gene (Uniprot):PADI6
Chain IDs:B (auth: C), C (auth: B)
Chain Length:694
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q6TGC4 Pfam ID:PF08526, PF08527, PF03068 EC:3.5.3.15
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-conjugating enzyme
Gene (Uniprot):UBE2D3
Chain IDs:D (auth: E), E (auth: D)
Chain Length:147
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P61077 Pfam ID:PF00179 EC:2.3.2.23
Ligand Molecules
NA
Primary Citation
The maternal PADI6-UHRF1-UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis.
Nat.Struct.Mol.Biol. 33 512 524 (2026)
PMID: 41772195 DOI: 10.1038/s41594-026-01758-y
Primary Citation of related structures
9LPK
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