9LLU image
Deposition Date 2025-01-17
Release Date 2026-07-22
Last Version Date 2026-09-23
Entry Detail
PDB ID:
9LLU
Keywords:
IMMUNE SYSTEM
Title:
p53 epitope specific TCR 4414A binding to p53Y220D-HLA-A2
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.87 Å
R-Value Free:
0.27
R-Value Work:
0.26
R-Value Observed:
0.26
Space Group:
I 1 2 1
9LLU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Gene (Uniprot):HLA-A
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8WLS4
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P61769 Pfam ID:PF07654
Polymer Type:polypeptide(L)
Molecule:VAL-VAL-PRO-ASP-GLU-PRO-PRO-G
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:T cell receptor 4414A chain a
Chain IDs:E (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:T cell receptor 4414A chain b
Chain IDs:D (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Structural basis for T-cell receptor recognition of p53 Y220D , a human cancer neoantigen.
Acta Crystallogr D Struct Biol 82 1082 1092 (2026)
PMID: 42599692 DOI: 10.1107/S2059798326007564
Primary Citation of related structures
9LLU
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