ISDA: 9LFC

Deposition Date 2025-01-08

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9LFC

Keywords:

MEMBRANE PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of human bradykinin receptor B1R bound to antagonist R715

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:B1 bradykinin receptor,Kappa-
Gene (Uniprot):OPRK1, BDKRB1
Mutagens:S124K/S132C
Chain IDs:A
Chain Length:340
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P46663,P41145 Pfam ID:PF00001

Protein Blast

Polymer Type:polypeptide(L)
Molecule:R715
Chain IDs:C (auth: B)
Chain Length:10
Number of Molecules:1
Biological Source:synthetic construct

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody 6
Chain IDs:B (auth: C)
Chain Length:171
Number of Molecules:1
Biological Source:Lama glama

Ligand Molecules

Primary Citation

Cryo-EM structure of human bradykinin receptor B1R bound to antagonist R715

Xia, M, Zhang, H.Show

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