9LEZ image
Deposition Date 2025-01-07
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9LEZ
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of human ZAC in complex with N-(4-(tert-butyl)thiazol-2-yl)-3-fluorobenzamide (TTFB)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Enterovirus A71 (Taxon ID: 39054)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.54 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9LEZ validation report missing
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ligand-gated cation channel Z
Gene (Uniprot):ZACN
Mutagens:A152T
Chain IDs:A (auth: D), B, C, D (auth: A), E
Chain Length:705
Number of Molecules:5
Biological Source:Homo sapiens, Enterovirus A71
UniProt ID:Q401N2,B6F2F5 Pfam ID:PF02931
Ligand Molecules
A1EKJ
ZN
Primary Citation
Structural basis of human zinc-activated channel (ZAC) signaling and modulation.
Cell Discov 12 ? ? (2026)
PMID: 41912481 DOI: 10.1038/s41421-026-00878-5
Primary Citation of related structures
9LEZ
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