ISDA: 9LET

Deposition Date 2025-01-07

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9LET

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of human ZAC in zinc Binding State

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Enterovirus A71 (Taxon ID: 39054)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.62 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ligand-gated cation channel Z
Gene (Uniprot):ZACN
Mutagens:A152T
Chain IDs:A, B, C (auth: E), D, E (auth: C)
Chain Length:705
Number of Molecules:5
Biological Source:Homo sapiens, Enterovirus A71

UniProt ID:Q401N2,B6F2F5 Pfam ID:PF02931

Ligand Molecules

Primary Citation

Structural basis of human zinc-activated channel (ZAC) signaling and modulation.

Zhou, Z, Long, Y, Chao, Y, Yang, C, Tang, Y.Q, Shu, Y, Zhu, H, Jensen, A.A, Qu, Q.Show

Cell Discov 12 ? ? (2026)

PMID: 41912481 DOI: 10.1038/s41421-026-00878-5

Primary Citation of related structures

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