ISDA: 9L89

Deposition Date 2024-12-27

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9L89

Keywords:

IMMUNE SYSTEM/DNA

Title:

Structure of human TREX1-DNA complex with K160R disease-associated mutation

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.38 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Three-prime repair exonucleas
Gene (Uniprot):TREX1
Mutagens:K160R
Chain IDs:A, B, E, F
Chain Length:242
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q9NSU2 EC:3.1.11.2

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*GP*TP*TP*GP*GP*CP
Chain IDs:C, D, G, H
Chain Length:22
Number of Molecules:4
Biological Source:synthetic construct

Primary Citation

Distinct recognition pattern for double-stranded DNA allows TREX1 to maintain immune homeostasis

Zhu, J, Wang, L, Lin, C, Zhou, W.Show

Immunity ? ? ? (2026)

Primary Citation of related structures

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