9L88 image
Deposition Date 2024-12-27
Release Date 2026-04-29
Last Version Date 2026-04-29
Entry Detail
PDB ID:
9L88
Keywords:
IMMUNE SYSTEM/DNA
Title:
Structure of human TREX1-DNA complex with K66R disease-associated mutation
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.62 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 1 21 1
9L88 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Three-prime repair exonucleas
Gene (Uniprot):TREX1
Mutagens:K66R
Chain IDs:A, B, E, F
Chain Length:242
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9NSU2 EC:3.1.11.2
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*GP*TP*TP*GP*GP*CP
Chain IDs:C, D, G, H
Chain Length:22
Number of Molecules:4
Biological Source:synthetic construct
Ligand Molecules
LI
Primary Citation
Distinct recognition pattern for double-stranded DNA allows TREX1 to maintain immune homeostasis
Immunity ? ? ? (2026)
Primary Citation of related structures
9L88
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