9L62 image
Deposition Date 2024-12-23
Release Date 2026-01-07
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9L62
Keywords:
TRANSFERASE
Title:
A novel allosteric covalent inhibitory site of fucosyltransferase 8 revealed by crystal structures
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.04 Å
R-Value Free:
0.27
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
C 1 2 1
9L62 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Alpha-(1,6)-fucosyltransferas
Gene (Uniprot):FUT8
Chain IDs:A, B
Chain Length:499
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9BYC5 Pfam ID:PF19745, PF14604 EC:2.4.1.68
Ligand Molecules
XC9
Primary Citation
Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression.
Nat Commun 17 ? ? (2026)
PMID: 41667477 DOI: 10.1038/s41467-026-68971-7
Primary Citation of related structures
9L62
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