ISDA: 9KZ8

Deposition Date 2024-12-10

Release Date 2025-11-26

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9KZ8

Keywords:

SIGNALING PROTEIN

Title:

Structure of EP67 bound mouse C3aR in complex with Go

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Spodoptera frugiperda, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.30 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAO1
Mutagens:G42D,E43N,A227D,G230D,I332A,V335I
Chain IDs:B (auth: A)
Chain Length:250
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P09471 Pfam ID:PF00503 EC:3.6.5.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF00400, PF25391

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Muscarinic acetylcholine rece
Gene (Uniprot):C3ar1, CHRM4
Chain IDs:A (auth: C)
Chain Length:533
Number of Molecules:1
Biological Source:Homo sapiens, Mus musculus

UniProt ID:P08173,O09047 Pfam ID:PF00001

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:EP67 ligand
Chain IDs:F (auth: D)
Chain Length:10
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Antibody fragment - ScFv16
Chain IDs:E (auth: H)
Chain Length:248
Number of Molecules:1
Biological Source:Mus musculus

Ligand Molecules

Primary Citation

Structural basis of complement anaphylatoxin receptor activation by an immunostimulant lead candidate.

Dalal, A, Yadav, M.K, Ganguly, M, Mishra, S, Yadav, R, Sinha, S, Roy, N, Tiwari, D, Mukherjee, D, Reyaz, A, Dsouza, C.A, Nigam, A, Banerjee, N, Li, X.X, Clark, R.J, Woodruff, T.M, Banerjee, R, Gati, C, Shukla, A.K.Show

Proc.Natl.Acad.Sci.USA 123 e2614459123 e2614459123 (2026)

PMID: 42418494 DOI: 10.1073/pnas.2614459123

Primary Citation of related structures

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