ISDA: 9KVF

Deposition Date 2024-12-05

Release Date 2025-08-20

Last Version Date 2026-09-02

Entry Detail

PDB ID:

9KVF

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of SARS-CoV-2 EG.1 spike protein in complex with triple-nAb 4A5, 4C1 and 2E10

Biological Source:

Source Organism(s):

Macaca mulatta (Taxon ID: 9544)
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Cricetulus griseus, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:2E10 light chain
Chain IDs:A
Chain Length:110
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:2E10 heavy chain
Chain IDs:E (auth: B)
Chain Length:122
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:4A5 heavy chain
Chain IDs:F (auth: C)
Chain Length:123
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:4A5 light chain
Chain IDs:G (auth: D)
Chain Length:107
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:4C1 light chain
Chain IDs:D (auth: E)
Chain Length:110
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:4C1 heavy chain
Chain IDs:C (auth: F)
Chain Length:128
Number of Molecules:1
Biological Source:Macaca mulatta

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein S1
Gene (Uniprot):S
Chain IDs:B (auth: G)
Chain Length:284
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC2 Pfam ID:PF09408, PF19209

Ligand Molecules

Primary Citation

Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants.

Wang, S, Sun, H, Wang, Y, Wang, Z, Yuan, L, Guo, H, Gao, J, Lan, M, Wu, Y, Shang, H, Chen, X, Chen, Z, Hu, J, Tang, Z, Wen, G, Ying, D, Liu, C, Jiang, Y, Su, J, Lin, M, Wu, T, Li, S, Zhang, T, Zhang, J, Guan, Y, Xia, N, Yuan, Q, Zheng, Q, Zhang, Y, Zheng, Z.Show

Proc.Natl.Acad.Sci.USA 122 e2503254122 e2503254122 (2025)

PMID: 40854137 DOI: 10.1073/pnas.2503254122

Primary Citation of related structures

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