ISDA: 9KVD

Deposition Date 2024-12-05

Release Date 2025-08-20

Last Version Date 2026-09-02

Entry Detail

PDB ID:

9KVD

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with triple-nAb 3G5, 4H5 and 4C11

Biological Source:

Source Organism(s):

Macaca mulatta (Taxon ID: 9544)
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Cricetulus griseus, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.44 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:The heavy chain of 4C11
Chain IDs:A
Chain Length:123
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:The light chain of 4C11
Chain IDs:B
Chain Length:107
Number of Molecules:1
Biological Source:Macaca mulatta

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein S1
Gene (Uniprot):S
Chain IDs:E (auth: C)
Chain Length:194
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC2,A0A8B1JP47 Pfam ID:PF09408

Polymer Type:polypeptide(L)
Molecule:The heavy chain of 4H5
Chain IDs:C (auth: D)
Chain Length:121
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:The heavy chain of 3G5
Chain IDs:F (auth: E)
Chain Length:120
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:The light chain of 4H5
Chain IDs:D (auth: F)
Chain Length:110
Number of Molecules:1
Biological Source:Macaca mulatta

Polymer Type:polypeptide(L)
Molecule:The light chain of 3G5
Chain IDs:G
Chain Length:113
Number of Molecules:1
Biological Source:Macaca mulatta

Ligand Molecules

NAG

Primary Citation

Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants.

Wang, S, Sun, H, Wang, Y, Wang, Z, Yuan, L, Guo, H, Gao, J, Lan, M, Wu, Y, Shang, H, Chen, X, Chen, Z, Hu, J, Tang, Z, Wen, G, Ying, D, Liu, C, Jiang, Y, Su, J, Lin, M, Wu, T, Li, S, Zhang, T, Zhang, J, Guan, Y, Xia, N, Yuan, Q, Zheng, Q, Zhang, Y, Zheng, Z.Show

Proc.Natl.Acad.Sci.USA 122 e2503254122 e2503254122 (2025)

PMID: 40854137 DOI: 10.1073/pnas.2503254122

Primary Citation of related structures

Feedback Form