ISDA: 9KOF

Deposition Date 2024-11-20

Release Date 2026-06-17

Last Version Date 2026-06-17

Entry Detail

PDB ID:

9KOF

Keywords:

GENE REGULATION

Title:

Structure of human PRC2 with SAH and H3K27me3 peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.07 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone-lysine N-methyltransf
Gene (Uniprot):EZH2
Chain IDs:A
Chain Length:718
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15910 Pfam ID:PF11616, PF18118, PF21358, PF18264, PF00856 EC:2.1.1.356

Protein Blast

Polymer Type:polypeptide(L)
Molecule:H3K27me3
Chain IDs:B (auth: C), D (auth: E)
Chain Length:7
Number of Molecules:2
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Polycomb protein EED
Gene (Uniprot):EED
Chain IDs:C (auth: D)
Chain Length:370
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O75530 Pfam ID:PF00400

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Zinc finger protein AEBP2
Gene (Uniprot):AEBP2
Chain IDs:F
Chain Length:106
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q6ZN18 Pfam ID:PF26014

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Polycomb protein SUZ12
Gene (Uniprot):SUZ12
Chain IDs:E (auth: G)
Chain Length:597
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15022 Pfam ID:PF23320, PF09733

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone-binding protein RBBP4
Gene (Uniprot):RBBP4
Chain IDs:G (auth: H)
Chain Length:407
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q09028 Pfam ID:PF12265, PF00400

Ligand Molecules

SAH

Primary Citation

Structure of human PRC2 with SAH and H3K27me3 peptide

Gao, H, Cao, T, Liu, Y, Liu, D, Yu, H, Qi, W.Show

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