ISDA: 9KL4

Deposition Date 2024-11-14

Release Date 2025-09-24

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9KL4

Keywords:

TRANSFERASE

Title:

Crystal structure of EGFR complexed with N-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.32 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

I 2 3

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Epidermal growth factor recep
Gene (Uniprot):EGFR
Chain IDs:A
Chain Length:330
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00533 Pfam ID:PF07714 EC:2.7.10.1

Ligand Molecules

A1L53

Primary Citation

TAS3351 is a brain penetrable EGFR-TKI that overcomes T790M and C797S resistant mutations.

Kasuga, H, Kataoka, Y, Yamamoto, F, Miyamoto, R, Tsuji, S, Suzuki, T, Mizuarai, S.Show

Commun Med (Lond) ? ? ? (2026)

PMID: 41882274 DOI: 10.1038/s43856-026-01546-1

Primary Citation of related structures

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