ISDA: 9K4T

Deposition Date 2024-10-21

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9K4T

Keywords:

HYDROLASE

Title:

Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state EB.3

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Saccharomyces cerevisiae (Taxon ID: 4932)

Expression System(s):

Homo sapiens, Saccharomyces cerevisiae

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

6.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC2
Chain IDs:A
Chain Length:433
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P35998 Pfam ID:PF21236, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC1
Chain IDs:B
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62191 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC5
Chain IDs:C
Chain Length:398
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62195 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC4
Chain IDs:D
Chain Length:418
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43686 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome 26S subunit, ATPas
Gene (Uniprot):PSMC6
Chain IDs:E
Chain Length:403
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:A0A087X2I1 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC3
Chain IDs:F
Chain Length:439
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P17980 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA6
Chain IDs:G, GA (auth: g)
Chain Length:246
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P60900 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA2
Chain IDs:H, HA (auth: h)
Chain Length:234
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25787 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA4
Chain IDs:I, IA (auth: i)
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25789 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA7
Chain IDs:J, JA (auth: j)
Chain Length:248
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O14818 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA5
Chain IDs:K, KA (auth: k)
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28066 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA1
Chain IDs:L, LA (auth: l)
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25786 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA3
Chain IDs:M, MA (auth: m)
Chain Length:255
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25788 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB6
Chain IDs:N, NA (auth: n)
Chain Length:239
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28072 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB7
Chain IDs:O, OA (auth: o)
Chain Length:277
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q99436 Pfam ID:PF00227, PF12465 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB3
Chain IDs:P, PA (auth: p)
Chain Length:205
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49720 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB2
Chain IDs:Q, QA (auth: q)
Chain Length:201
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49721 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB5
Chain IDs:R, RA (auth: r)
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28074 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB1
Chain IDs:S, SA (auth: s)
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P20618 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB4
Chain IDs:T, TA (auth: t)
Chain Length:264
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28070 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD1
Chain IDs:U
Chain Length:953
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q99460 Pfam ID:PF21505, PF01851, PF13646, PF18004 EC:5.6.1.5

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD3
Chain IDs:V
Chain Length:534
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O43242 Pfam ID:PF25573, PF01399, PF08375

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD12
Chain IDs:W
Chain Length:456
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O00232 Pfam ID:PF22241, PF01399, PF18098

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD11
Chain IDs:X
Chain Length:422
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O00231 Pfam ID:PF18055, PF01399, PF18503

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD6
Chain IDs:Y
Chain Length:389
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15008 Pfam ID:PF10602, PF01399, PF21154

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD7
Chain IDs:Z
Chain Length:324
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P51665 Pfam ID:PF01398, PF13012

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD13
Chain IDs:AA (auth: a)
Chain Length:376
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UNM6 Pfam ID:PF22037, PF01399

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD4
Chain IDs:BA (auth: b)
Chain Length:377
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P55036 Pfam ID:PF13519, PF02809

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD14
Chain IDs:CA (auth: c)
Chain Length:310
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O00487 Pfam ID:PF01398, PF23594 EC:3.4.19.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD8
Chain IDs:DA (auth: d)
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P48556 Pfam ID:PF10075

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome complex subuni
Gene (Uniprot):SEM1
Chain IDs:EA (auth: e)
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P60896 Pfam ID:PF05160

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD2
Chain IDs:FA (auth: f)
Chain Length:908
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13200 Pfam ID:PF17781, PF01851, PF18051

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin
Gene (Uniprot):RPS27A
Chain IDs:UA (auth: u), WA (auth: z)
Chain Length:76
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62979 Pfam ID:PF00240

Polymer Type:polypeptide(L)
Molecule:Substrate
Chain IDs:VA (auth: v)
Chain Length:28
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae

Ligand Molecules