ISDA: 9JX4

Deposition Date 2024-10-11

Release Date 2026-04-15

Last Version Date 2026-10-14

Entry Detail

PDB ID:

9JX4

Keywords:

OXIDOREDUCTASE

Title:

Crystal Structure of an aldehyde-alcohol dehydrogenase in complex with metformin

Biological Source:

Source Organism(s):

Anaerobutyricum hallii (Taxon ID: 39488)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Aldehyde-alcohol dehydrogenas
Gene (Uniprot):adhE_1
Chain IDs:A
Chain Length:374
Number of Molecules:1
Biological Source:Anaerobutyricum hallii

UniProt ID:A0A174BVF5

Ligand Molecules

MF8

Primary Citation

Microbial aldehyde-alcohol dehydrogenase degrades metformin to limit therapeutic response in type 2 diabetes.

Zhao, Y, Peng, C, Xia, Y, Dong, T, Xu, J, Shan, X, Zhong, X, Xue, J, Bing, Z, Li, P, Han, J, Nie, Y, He, K, Cao, Y, Wang, T.Show

Cell Metab. ? ? ? (2026)

PMID: 42810351 DOI: 10.1016/j.cmet.2026.09.003

Primary Citation of related structures

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