ISDA: 9JWJ

Deposition Date 2024-10-10

Release Date 2025-10-15

Last Version Date 2025-10-15

Entry Detail

PDB ID:

9JWJ

Keywords:

TRANSCRIPTION

Title:

Structure of Human HDAC2 in complex with inhibitor N-(2-amino-5-(furan-2-yl)phenyl)-4-(1-((phenylsulfonyl)methyl)-1H-1,2,3-triazol-4-yl)benzamid

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.78 Å

R-Value Free:

0.20

R-Value Work:

0.15

R-Value Observed:

0.16

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone deacetylase 2
Gene (Uniprot):HDAC2
Chain IDs:A, B, C
Chain Length:404
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:Q92769 Pfam ID:PF00850 EC:3.5.1.98

Ligand Molecules

A1L4X

EDO

GOL

PEG

PG4

PGE

Primary Citation

Discovery of an HDAC2-selective inhibitor based on enzyme-inhibitor binding thermodynamics and kinetics, and its potential as a therapeutic drug for neurological disorders

Tojo, T, Itoh, Y, Kurohara, T, Li, Y, Singh, R, Narozny, R, Wiel, A, Miyake, Y, Yamashita, Y, Kusakabe, K, Uchida, S, Suzuki, T.Show

To be published ? ? ? (?)

Primary Citation of related structures

Feedback Form