ISDA: 9JBV

Deposition Date 2024-08-27

Release Date 2025-09-10

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9JBV

Keywords:

BLOOD CLOTTING

Title:

Structure of Engineered Coagulation Factor VIII with Enhanced Secretion and Coagulation Potential

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.17 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Coagulation factor VIII
Gene (Uniprot):F8
Chain IDs:A
Chain Length:1457
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00451 Pfam ID:PF07732, PF07731, PF00754

Ligand Molecules

Primary Citation

Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy.

Kashiwakura, Y, Nakajima, Y, Horinaka, K, Lopes, T.J.S, Furuta, Y, Yamaguchi, Y, Baatartsogt, N, Hayakawa, M, Katakai, Y, Uchiyama, S, Nureki, O, Nogami, K, Ohmori, T.Show

Blood 147 402 415 (2026)

PMID: 41198051 DOI: 10.1182/blood.2025028481

Primary Citation of related structures

Feedback Form