9J6S image
Deposition Date 2024-08-17
Release Date 2026-03-04
Last Version Date 2026-09-16
Entry Detail
PDB ID:
9J6S
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of human dopamine transporter in complex with tesofensine
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.80 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9J6S validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sodium-dependent dopamine tra
Gene (Uniprot):SLC6A3
Chain IDs:A
Chain Length:562
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q01959 Pfam ID:PF00209
Ligand Molecules
A1EA1
CL
CLR
NA
Y01
Primary Citation
Structural basis for pharmacotherapeutic action of triple reuptake inhibitors.
Nat Commun 17 61 61 (2025)
PMID: 41392177 DOI: 10.1038/s41467-025-66670-3
Primary Citation of related structures
9J6S
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