9J37 image
Deposition Date 2024-08-08
Release Date 2025-08-13
Last Version Date 2026-08-26
Entry Detail
PDB ID:
9J37
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of human Alpha-7 nicotinic acetylcholine receptor
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9J37 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Neuronal acetylcholine recept
Gene (Uniprot):CHRNA7
Chain IDs:A, B, C, D, E
Chain Length:0
Number of Molecules:5
Biological Source:Homo sapiens
UniProt ID:P36544 Pfam ID:PF02931, PF02932
Ligand Molecules
CLR
NAG
Primary Citation
Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting alpha 7 nicotinic acetylcholine receptor.
Acta Pharm Sin B 16 4147 4165 (2026)
PMID: 42453416 DOI: 10.1016/j.apsb.2025.12.035
Primary Citation of related structures
9J37
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