ISDA: 9IUN

Deposition Date 2024-07-22

Release Date 2025-07-30

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9IUN

Keywords:

LIGASE

Title:

Crystal structure of Trim25 Pspry

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.26

R-Value Work:

0.21

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin/ISG15 ligase TRI
Gene (Uniprot):TRIM25
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:205
Number of Molecules:12
Biological Source:Homo sapiens

UniProt ID:Q14258 Pfam ID:PF13765, PF00622 EC:2.3.2.27

Primary Citation

The structural basis of TRIM25-mediated regulation of RIG-I.

Li, Y, Wu, S, Tian, X, Kong, C, Hong, W, Xiao, T, Wang, S, Wei, Z, Su, Z, Ren, H, Song, Y, Hu, L, Lin, D, Yao, H, Han, J, Chen, X, Lin, T.Show

J.Biol.Chem. 301 108367 108367 (2025)

PMID: 40024477 DOI: 10.1016/j.jbc.2025.108367

Primary Citation of related structures

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