ISDA: 9HXA

Deposition Date 2025-01-07

Release Date 2025-02-12

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9HXA

Keywords:

PROTEIN FIBRIL

Title:

In vitro grown K58N Alpha-Synuclein Fibrils

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.70 Å

Aggregation State:

FILAMENT

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha-synuclein
Gene (Uniprot):SNCA
Chain IDs:A (auth: C), B (auth: A)
Chain Length:140
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P37840 Pfam ID:PF01387

Ligand Molecules

Primary Citation

A Novel alpha-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease.

Al-Azzani, M, Weber, S, Ramalingam, N, Ramon, M, Shvachiy, L, Mestre, G, Zech, M, Sicking, K, de Opakua, A.I, Jayanthi, V, Amaral, L, Agarwal, A, Chandran, A, Chaves, S.R, Winkelmann, J, Trenkwalder, C, Schwager, M, Pauli, S, Dettmer, U, Fernandez, C.O, Lautenschlager, J, Zweckstetter, M, Fernandez-Busnadiego, R, Mollenhauer, B, Outeiro, T.F.Show

Mov Disord 40 2732 2745 (2025)

PMID: 40905240 DOI: 10.1002/mds.70030

Primary Citation of related structures

Feedback Form