ISDA: 9HWE

Deposition Date 2025-01-03

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9HWE

Keywords:

TRANSCRIPTION

Title:

SMAD4 MH2, residues 314-552

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.70 Å

R-Value Free:

0.19

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

F 41 3 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mothers against decapentapleg
Gene (Uniprot):SMAD4
Chain IDs:A
Chain Length:240
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13485 Pfam ID:PF03166

Ligand Molecules

EDO

SO4

Primary Citation

(RUNNING TITLE:) Insights into the structure-activity relationship of SMAD4 variants linked to Myhre syndrome and hereditary hemorrhagic telangiectasia

Torner, C, Condeminas, M, Pluta, R, Aragon, E, Khan, R.J, Martin-Malpartida, P, Rodriguez de Regil, M, Pous, J, Humm, A.-S, Niebling, S, Garcia-Alai, M, Marquez, J.A, Martinez, A, Macias, M.J.Show

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Primary Citation of related structures

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