ISDA: 9HW8

Deposition Date 2025-01-03

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9HW8

Keywords:

LYASE

Title:

Variant H343A of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the product UMP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.50 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Uridine 5'-monophosphate synt
Mutagens:H343A
Chain IDs:A, B
Chain Length:258
Number of Molecules:2
Biological Source:Homo sapiens

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
CSS	A	CYS	modified residue

Ligand Molecules

U5P

Primary Citation

Variant H343A of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the product UMP

Kirck, L.L, Tittmann, K.Show

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Primary Citation of related structures

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