ISDA: 9HUF

Deposition Date 2024-12-22

Release Date 2026-02-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9HUF

Keywords:

MEMBRANE PROTEIN

Title:

Outward-open structure of human glycine transporter 2 bound to allosteric inhibitor RPI-GLYT2-82

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.79 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Sodium- and chloride-dependen
Mutagens:delta 2-185
Chain IDs:A
Chain Length:613
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1IXX

CLR

Y01

Primary Citation

A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects.

Cantwell Chater, R.P, Peiser-Oliver, J, Pati, T.K, Quinn, A.S, Lotsaris, I, Frangos, Z.J, Anderson, K.E, Tischer, A.E, Williams-Noonan, B.J, Aubrey, K.R, O'Mara, M.L, Michaelides, M, Mohammadi, S.A, Cioffi, C.L, Vandenberg, R.J, Shahsavar, A, Cantwell Chater, R.P, Peiser-Oliver, J, Pati, T.K, Quinn, A.S, Lotsaris, I, Frangos, Z.J, Anderson, K.E, Tischer, A.E, Williams-Noonan, B.J, Aubrey, K.R, O'Mara, M.L, Michaelides, M, Mohammadi, S.A, Cioffi, C.L, Vandenberg, R.J, Shahsavar, A.Show

Biorxiv ? ? ? (2025)

PMID: 41332641 DOI: 10.1101/2025.04.21.649698

Primary Citation of related structures

Feedback Form