ISDA: 9HMI

Deposition Date 2024-12-09

Release Date 2026-05-20

Last Version Date 2026-05-20

Entry Detail

PDB ID:

9HMI

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of the Calf domains of Integrin Alpha5 in complex with angiopoietin2 peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Baculovirus expression vector pfastbac1-hm

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.78 Å

R-Value Free:

0.30

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Integrin alpha-5
Gene (Uniprot):ITGA5
Chain IDs:A
Chain Length:359
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P08648 Pfam ID:PF20805, PF20806

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Angiopoietin-2
Gene (Uniprot):ANGPT2
Chain IDs:B (auth: P)
Chain Length:9
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O15123

Ligand Molecules

NAG

Primary Citation

Angiopoietin-2 interactions with active vs inactive alpha5beta1-integrin at cell-cell junctions determine TIE2-FOXO1 pathway activation

Sipila, T, Murthy, A.V, Ponna, S.K, Pink, A, Enkavi, G, Vattulainen, I, Leppanen, V.M, Saharinen, P.Show

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Primary Citation of related structures

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