9H4B image
Deposition Date 2024-10-18
Release Date 2025-10-29
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9H4B
Keywords:
ANTIVIRAL PROTEIN
Title:
Crystal structure of SARS-CoV-2 Mpro in complex with GK-730
Biological Source:
Source Organism(s):
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.90 Å
R-Value Free:
0.23
R-Value Work:
0.17
Space Group:
C 1 2 1
9H4B validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Chain IDs:A
Chain Length:306
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2
UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48
Ligand Molecules
A1ISK
Primary Citation
Thiazolyl 4-carboxylate ketone as a new warhead for a highly potent SARS-CoV-2 main protease inhibitor.
Eur.J.Med.Chem. 303 118436 118436 (2026)
PMID: 41344111 DOI: 10.1016/j.ejmech.2025.118436
Primary Citation of related structures
9H4B
Feedback Form
Name
Email
Institute
Feedback