ISDA: 9GOO

Deposition Date 2024-09-05

Release Date 2025-09-17

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9GOO

Keywords:

LYASE

Title:

Crystal structure of human carbonic anhydrase II in complex with PCI-27483

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.40 Å

R-Value Free:

0.19

R-Value Work:

0.15

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Carbonic anhydrase 2
Gene (Uniprot):CA2
Chain IDs:A (auth: AAA)
Chain Length:260
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00918 Pfam ID:PF00194 EC:4.2.1.1

Ligand Molecules

A1IOK

EDO

Primary Citation

Exploring the Polypharmacological Potential of PCI-27483: A Selective Inhibitor of Carbonic Anhydrases IX and XII.

D'Agostino, I, Bonardi, A, Ferraroni, M, Gratteri, P, Angeli, A, Supuran, C.T.Show

Acs Med.Chem.Lett. 15 2042 2045 (2024)

PMID: 39563799 DOI: 10.1021/acsmedchemlett.4c00443

Primary Citation of related structures

Feedback Form