ISDA: 9GMP

Deposition Date 2024-08-29

Release Date 2025-09-24

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9GMP

Keywords:

SIGNALING PROTEIN

Title:

TKUL kinase domain from Leishmania mexicana

Biological Source:

Source Organism(s):

Leishmania mexicana (Taxon ID: 5665)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.89 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 2 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein (Map
Gene (Uniprot):LMXM_34_4000
Chain IDs:A
Chain Length:285
Number of Molecules:1
Biological Source:Leishmania mexicana

UniProt ID:E9B6S8 Pfam ID:PF00069

Ligand Molecules

GOL

PEG

Primary Citation

A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity.

Fokkens, T.J, Rauh, E.T, Wolter, M, Sebald, H, Mitnacht, M, Ainatzi, S, Sprick, S, Teschke, L, Eisenhuth, N, Huibregtse, J.M, Butter, F, Urlaub, H, Karnkowska, A, Steinchen, W, Schleicher, U, Janzen, C.J, Lorenz, S.Show

Mol.Cell 85 3711 3728.e11 (2025)

PMID: 40997810 DOI: 10.1016/j.molcel.2025.09.002

Primary Citation of related structures

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