ISDA: 9FM0

Deposition Date 2024-06-05

Release Date 2025-06-18

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9FM0

Keywords:

IMMUNE SYSTEM

Title:

Human antibody (Fab) and P. aeruginosa (T3SS) protein PcrV-fragment complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Pseudomonas aeruginosa (Taxon ID: 287)

Expression System(s):

Homo sapiens, Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.56 Å

R-Value Free:

0.23

R-Value Work:

0.20

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Human Fab Heavy Chain (FabHC)
Chain IDs:A, B
Chain Length:225
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Human Fab Light Chain (FabLC)
Chain IDs:C, D
Chain Length:214
Number of Molecules:2
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Type III secretion protein Pc
Gene (Uniprot):pcrV
Chain IDs:E, F
Chain Length:131
Number of Molecules:2
Biological Source:Pseudomonas aeruginosa

UniProt ID:G3XD49 Pfam ID:PF04792

Ligand Molecules

PEG

Primary Citation

Neutralizing human monoclonal antibodies that target the PcrV component of the type III secretion system of Pseudomonas aeruginosa act through distinct mechanisms.

Desveaux, J.M, Faudry, E, Contreras-Martel, C, Cretin, F, Dergan-Dylon, L.S, Amen, A, Bally, I, Tardivy-Casemajor, V, Chenavier, F, Fouquenet, D, Caspar, Y, Attree, I, Dessen, A, Poignard, P.Show

Elife 14 ? ? (2026)

PMID: 41700594 DOI: 10.7554/eLife.105195

Primary Citation of related structures

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