ISDA: 9F5V

Deposition Date 2024-04-30

Release Date 2025-05-14

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9F5V

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of thiol peroxidase from Helicobacter pylori (HpTx, reduced)

Biological Source:

Source Organism(s):

Helicobacter pylori (Taxon ID: 210)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.75 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Thiol peroxidase
Gene (Uniprot):tpx
Chain IDs:A, B
Chain Length:188
Number of Molecules:2
Biological Source:Helicobacter pylori

UniProt ID:O25151 Pfam ID:PF08534

Primary Citation

Metronidazole and ether derivatives target Helicobacter pylori via simultaneous stress induction and inhibition.

Fiedler, M.K, Pandler, M.S.I, Gong, R, Fuchs, S, Rox, K, Friedrich, V, Pfeiffer, D, Singh, D, Reinhardt, T, Mibus, C, Huber, M, Hess, C.R, Mejias-Luque, R, Gerhard, M, Groll, M, Sieber, S.A.Show

Nat Microbiol 11 1049 1063 (2026)

PMID: 41851492 DOI: 10.1038/s41564-026-02291-w

Primary Citation of related structures

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