9EW5 image
Deposition Date 2024-04-03
Release Date 2025-04-16
Last Version Date 2026-03-04
Entry Detail
PDB ID:
9EW5
Keywords:
PEPTIDE BINDING PROTEIN
Title:
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) 12mer and compound 23 (1083848)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.50 Å
R-Value Free:
0.21
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 2 21 21
9EW5 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:14-3-3 protein sigma
Gene (Uniprot):SFN
Chain IDs:A, C (auth: D)
Chain Length:236
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P31947 Pfam ID:PF00244
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RAF proto-oncogene serine/thr
Gene (Uniprot):RAF1
Chain IDs:B (auth: C), D (auth: F)
Chain Length:11
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P04049 EC:2.7.10.2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP B SER modified residue
Ligand Molecules
CA
MG
WQI
Primary Citation
Modulation of the 14-3-3 sigma /C-RAF "Auto"inhibited Complex by Molecular Glues.
J. Am. Chem. Soc. 148 4951 4965 (2026)
PMID: 41617210 DOI: 10.1021/jacs.5c12622
Primary Citation of related structures
9EW5
Feedback Form
Name
Email
Institute
Feedback