ISDA: 9ESD

Deposition Date 2024-03-26

Release Date 2025-03-05

Last Version Date 2025-03-05

Entry Detail

PDB ID:

9ESD

Keywords:

OXIDOREDUCTASE

Title:

Holo TDO with a bound inhibitor

Biological Source:

Source Organism(s):

Drosophila melanogaster (Taxon ID: 7227)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.25

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 63

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tryptophan 2,3-dioxygenase
Gene (Uniprot):v
Chain IDs:A, B, C, D
Chain Length:365
Number of Molecules:4
Biological Source:Drosophila melanogaster

UniProt ID:P20351 Pfam ID:PF03301 EC:1.13.11.11

Ligand Molecules

5PK

HEM

Primary Citation

SAR and cellular potency optimization of novel heme-binding IDO1 inhibitors

Cren, S, Lotz, C, Mac Sweeney, A, Lange, R, Kimmerlin, T.Show

To be published ? ? ? (?)

Primary Citation of related structures

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