ISDA: 9ELC

Deposition Date 2024-12-04

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9ELC

Keywords:

HYDROLASE/INHIBITOR

Title:

Structure of glucocerebrosidase in complex with a covalent inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Unidentified

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucosylceramidase
Chain IDs:A, B
Chain Length:497
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:B2R6A7 EC:3.2.1.45

Ligand Molecules

A1BLE

EDO

NAG

SO4

Primary Citation

Irreversible inhibitors and activity-based probes, derived from an adaptable conduritol aziridine scaffold, for studying glucocerebrosidase and GBA2 in vitro and in vivo

Wang, S, Tavassoly, O, Chowdhury, M.A, Carter, L, Brown, D, Bravo, R.C, Zhang, Z, Tesolin, D, Quartey, M.A, Pluvinage, B, Nyarko, J.N, Kumar, M, Feldman, R.A, Boraston, A.B, Mousseau, D.D, van der Spoel, A.C, Phenix, C.P.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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