9EJA image
Deposition Date 2024-11-27
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9EJA
Keywords:
ISOMERASE/DNA
Title:
Human FANCJ helicase bound to a fork DNA in the closed state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9EJA validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Fanconi anemia group J protei
Gene (Uniprot):BRIP1
Chain IDs:A
Chain Length:1271
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BX63 Pfam ID:PF06733, PF13307 EC:3.6.4.12
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*GP*AP*AP*AP*AP*CP
Chain IDs:B
Chain Length:44
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
AGS
MG
SF4
Primary Citation
Cryo-EM structures of human FANCJ reveal the mechanism of G-quadruplex unwinding and disease-associated mutations.
Nat Commun ? ? ? (2026)
PMID: 42457705 DOI: 10.1038/s41467-026-75715-0
Primary Citation of related structures
9EJA
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