ISDA: 9ECK

Deposition Date 2024-11-14

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9ECK

Keywords:

SIGNALING PROTEIN/INHIBITOR

Title:

Estrogen receptor alpha

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.20 Å

R-Value Free:

0.29

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Estrogen receptor
Gene (Uniprot):ESR1
Mutagens:C381S, C417S, L536S
Chain IDs:A, B, C, D
Chain Length:259
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P03372 Pfam ID:PF00104

Ligand Molecules

A1BHJ

Primary Citation

Human Estrogen Receptor Ligand-Binding Domain Complexed with an Orally Bioavailable, Potent and Selective Degrader.

Hegde, S, Zhang, G, Huang, P, Bunker, K.Show

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Primary Citation of related structures

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