9DSR image
Deposition Date 2024-09-28
Release Date 2025-10-01
Last Version Date 2026-09-09
Entry Detail
PDB ID:
9DSR
Keywords:
IMMUNE SYSTEM
Title:
Crystal structure of Fab MS-1805 in complex with NPNA3 peptide from circumsporozoite protein
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Plasmodium falciparum 3D7 (Taxon ID: 36329)
Expression System(s):
Cricetulus griseus, Synthetic construct
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.25 Å
R-Value Free:
0.23
R-Value Work:
0.18
R-Value Observed:
0.19
Space Group:
P 1 21 1
9DSR validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Heavy chain of Fab MS-1805
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Light chain of Fab MS-1805
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Circumsporozoite protein
Gene (Uniprot):CSP
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:Plasmodium falciparum 3D7
UniProt ID:Q7K740
Primary Citation
Engineered antibodies preserve structural and functional recognition of Plasmodium falciparum circumsporozoite protein.
Protein Sci. 35 e70738 e70738 (2026)
PMID: 42560026 DOI: 10.1002/pro.70738
Primary Citation of related structures
9DST
9DSU
9DSS
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