ISDA: 9D36

Deposition Date 2024-08-09

Release Date 2025-08-13

Last Version Date 2026-02-25

Entry Detail

PDB ID:

9D36

Keywords:

PROTEIN BINDING/INHIBITOR

Title:

Structure of the C-terminal Domain of RAGE and Its Inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

10000

Conformers Submitted:

Selection Criteria:

target function

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Advanced glycosylation end pr
Gene (Uniprot):AGER
Chain IDs:A
Chain Length:43
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15109

Ligand Molecules

A1A2E

Primary Citation

RAGE-mediated activation of the formin DIAPH1 and human macrophage inflammation are inhibited by a small molecule antagonist.

Theophall, G.G, Manigrasso, M.B, Nazarian, P, Premo, A, Reverdatto, S, Yepuri, G, Burz, D.S, Vanegas, S.M, Mangar, K, Zhao, Y, Li, H, DeVita, R.J, Ramasamy, R, Schmidt, A.M, Shekhtman, A.Show

Cell Chem Biol 32 1221 1234.e8 (2025)

PMID: 41038162 DOI: 10.1016/j.chembiol.2025.09.004

Primary Citation of related structures

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